Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells

1 Jun 2008

Abstract excerpt

Tight junctions have recently emerged as essential signaling regulators of proliferation and differentiation in epithelial tissues. Here, we aimed to identify the factors regulating claudin-7 expression in the colon, and analyzed the consequences of claudin-7 overexpression in colorectal carcinoma (CRC). In healthy human colonic crypts, claudin-7 expression was found to be low in the stem/progenitor cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Barrier Structure and Function Studies
Share to Cancer Cells and Metastasis
Share to Cancer-related molecular mechanisms research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18519685
DOI: 10.1158/0008-5472.can-07-5805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer CellsPMID 18519685Read ↗

Claudin-7 deficiency promotes stemness properties in colorectal cancer through Sox9-mediated Wnt/β-catenin signallingSemantic proximity Read ↗

Emerging clinical significance of claudin-7 in colorectal cancer: a reviewSemantic proximity Read ↗

Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesisSemantic proximity Read ↗

β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers.Semantic proximity Read ↗

The level of claudin-7 is reduced as an early event in colorectal carcinogenesisSemantic proximity Read ↗

SOX9 suppresses colon cancer via inhibiting epithelial-mesenchymal transition and SOX2 inductionSemantic proximity Read ↗

Expression of the Carcinoembryonic Antigen Gene Is Inhibited by SOX9 in Human Colon Carcinoma CellsSemantic proximity Read ↗

The p53-inducible CLDN7 regulates colorectal tumorigenesis and has prognostic significance.Semantic proximity Read ↗

The Expression of the Claudin Family of Proteins in Colorectal CancerSemantic proximity Read ↗

A Complex of EpCAM, Claudin-7, CD44 Variant Isoforms, and Tetraspanins Promotes Colorectal Cancer ProgressionSemantic proximity Read ↗

Analysis of SOX9 Expression in Colorectal CancerSemantic proximity Read ↗

Distinct levels of <i>Sox9</i> expression mark colon epithelial stem cells that form colonoids in cultureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.