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Article

Functional genetic validation of key genes conferring insecticide resistance in the major African malaria vector, Anopheles gambiae.

Proceedings of the National Academy of Sciences of the United States of America - 17 Dec 2019

Adolfi Adriana, Poulton Beth, Anthousi Amalia, Macilwee Stephanie, Ranson Hilary, Lycett Gareth J

Abstract excerpt

Resistance in Anopheles gambiae to members of all 4 major classes (pyrethroids, carbamates, organochlorines, and organophosphates) of public health insecticides limits effective control of malaria transmission in Africa. Increase in expression of detoxifying enzymes has been associated with insecticide resistance, but their direct functional validation in An. gambiae is still lacking. Here, we perform transgenic...

Topics

Animals
Animals, Genetically Modified
Anopheles
Cytochrome P-450 Enzyme System
Female
Genes, Insect
Genomics
Glutathione Transferase
Insecticide Resistance
Insecticides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Malaria

Male

Mosquito Vectors

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 31801878
DOI: 10.1073/pnas.1914633116
PMCID: PMC6926047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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