Article
Synergistic action of different molecular mechanisms causes striking levels of insecticide resistance in the malaria vector Anopheles gambiae.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2026
Chen Mengling, Remadi Latifa, Tsakireli Dimitra, Kokkas Emmanouil, Balaska Sofia, Teta Sibora, M F Ooi Jocelyn, Hemingway Janet, Paine Mark J I, Lycett Gareth J, Vontas John, Grigoraki Linda
Abstract excerpt
Intensifying insecticide resistance in the malaria vector Anopheles gambiae poses a serious threat to the progress achieved the last decades in reducing malaria deaths in Africa. The genetic basis of insecticide resistance is often complex, involving multiple genes and mutations. However, we still lack a clear understanding of how each mechanism contributes to overall resistance and how highly resistant...
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