Article
Mutations in the Neuraminidase-Like Protein of Bat Influenza H18N11 Virus Enhance Virus Replication in Mammalian Cells, Mice, and Ferrets.
Journal of virology - 14 Feb 2020
Zhong Gongxun, Fan Shufang, Hatta Masato, Nakatsu Sumiho, Walters Kevin B, Lopes Tiago J S, Wang Jessica I-Hsuan, Ozawa Makoto, Karasin Alexander, Li Yan, Tong Suxiang, Donis Ruben O, Neumann Gabriele, Kawaoka Yoshihiro
Abstract excerpt
To characterize bat influenza H18N11 virus, we propagated a reverse genetics-generated H18N11 virus in Madin-Darby canine kidney subclone II cells and detected two mammal-adapting mutations in the neuraminidase (NA)-like protein (NA-F144C and NA-T342A, N2 numbering) that increased the virus titers in three mammalian cell lines (i.e., Madin-Darby canine kidney, Madin-Darby canine kidney subclone II, and human lung...
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