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Article

Characterization of Uncultivable Bat Influenza Virus Using a Replicative Synthetic Virus

2 Oct 2014

Abstract excerpt

Bats harbor many viruses, which are periodically transmitted to humans resulting in outbreaks of disease (e.g., Ebola, SARS-CoV). Recently, influenza virus-like sequences were identified in bats; however, the viruses could not be cultured. This discovery aroused great interest in understanding the evolutionary history and pandemic potential of bat-influenza. Using synthetic genomics, we were unable to rescue the...

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PMID: 25275541
DOI: 10.1371/journal.ppat.1004420

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