Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.

doi:10.1001/jamaneurol.2020.2231

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Article

Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.

JAMA neurology - 1 Nov 2020

Dubey Divyanshu, Wilson Michael R, Clarkson Benjamin, Giannini Caterina, Gandhi Manish, Cheville John, Lennon Vanda A, Eggers Scott, Devine Michelle F, Mandel-Brehm Caleigh, Kryzer Thomas, Hinson Shannon R, Khazaie Khashayarsha, Hales Chadwick, Kattah Jorge, Pavelko Kevin D, Andrews Patrick, Eaton James E, Jitprapaikulsan Jiraporn, Mills John R, Flanagan Eoin P, Zekeridou Anastasia, Leibovich Bradley, Fryer James, Torre Matthew, Kaufman Charles, Thoreson James B, Sagen Jessica, Linnoila Jenny J, DeRisi Joseph L, Howe Charles L, McKeon Andrew, Pittock Sean J

Abstract excerpt

Importance: Recognizing the presenting and immunopathological features of Kelch-like protein-11 immunoglobulin G seropositive (KLHL11 IgG+) patients may aid in early diagnosis and management. Objective: To describe expanding neurologic phenotype, cancer associations, outcomes, and immunopathologic features of KLHL11 encephalitis. Design, Setting, and Participants: This retrospective tertiary care center study,...

Topics

Adult
Aged
Autoantibodies
Biomarkers
Carrier Proteins
Encephalitis
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Follow-Up Studies

Humans

Male

Middle Aged

Paraneoplastic Syndromes, Nervous System

Phenotype

Retrospective Studies

T-Lymphocytes

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Identifiers

PMID: 32744608
DOI: 10.1001/jamaneurol.2020.2231
PMCID: PMC7653501

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