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Article

A split NanoLuc complementation-based human norovirus-like particle entry assay facilitates evaluation of anti-norovirus antibodies in live cells.

Antiviral research - 1 Jan 2022

Qiao Weihua, Wang Shuxia, Zhang Chao, Huang Zhong

Abstract excerpt

Human noroviruses (NoVs) are the most common cause of acute gastroenteritis worldwide. One major obstacle in developing NoV vaccines is the lack of robust cell culture for efficacy evaluation. In this study, we successfully developed a NoV virus-like particle (VLP) entry assay based on split NanoLuc luciferase (LgBiT and HiBiT) complementation. HiBiT-tagged NoV GII.4 VLP (VLP-HiBiT) can be efficiently produced in...

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PMID: 34965447
DOI: 10.1016/j.antiviral.2021.105231

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