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Article

Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage.

Nature communications - 3 Dec 2019

Bolderson Emma, Burgess Joshua T, Li Jun, Gandhi Neha S, Boucher Didier, Croft Laura V, Beard Samuel, Plowman Jennifer J, Suraweera Amila, Adams Mark N, Naqi Ali, Zhang Shu-Dong, Sinclair David A, O'Byrne Kenneth J, Richard Derek J

Abstract excerpt

The DNA repair capacity of human cells declines with age, in a process that is not clearly understood. Mutation of the nuclear envelope protein barrier-to-autointegration factor 1 (Banf1) has previously been shown to cause a human progeroid disorder, Néstor-Guillermo progeria syndrome (NGPS). The underlying links between Banf1, DNA repair and the ageing process are unknown. Here, we report that Banf1 controls the...

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Identifiers

PMID: 31796734
DOI: 10.1038/s41467-019-13167-5
PMCID: PMC6890647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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