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Article

Barrier-to-autointegration factor (BAF) involvement in prelamin A-related chromatin organization changes.

Oncotarget - 29 Mar 2016

Loi Manuela, Cenni Vittoria, Duchi Serena, Squarzoni Stefano, Lopez-Otin Carlos, Foisner Roland, Lattanzi Giovanna, Capanni Cristina

Abstract excerpt

Chromatin disorganization is one of the major alterations linked to prelamin A processing impairment. In this study we demonstrate that BAF is necessary to modulate prelamin A effects on chromatin structure. We show that when prelamin A and BAF cannot properly interact no prelamin A-dependent effects on chromatin occur; similar to what is observed in human Nestor Guillermo Progeria Syndrome cells harboring a BAF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26701887
DOI: 10.18632/oncotarget.6697
PMCID: PMC4941268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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