Article
Evaluation of somatic mutations in cervicovaginal samples as a non-invasive method for the detection and molecular classification of endometrial cancer.
EBioMedicine - 1 Aug 2023
Pelegrina Beatriz, Paytubi Sonia, Marin Fátima, Martínez José Manuel, Carmona Álvaro, Frias-Gomez Jon, Peremiquel-Trillas Paula, Dorca Eduard, Zanca Alba, López-Querol Marta, Onieva Irene, Benavente Yolanda, Barahona Marc, Fernandez-Gonzalez Sergi, De Francisco Javier, Caño Víctor, Vidal August, Pijuan Lara, Canet-Hermida Júlia, Dueñas Núria, Brunet Joan, Pineda Marta, Matias-Guiu Xavier, Ponce Jordi, Bosch Francesc Xavier, De Sanjosé Silvia, Alemany Laia, Costas Laura
Abstract excerpt
BACKGROUND: The incidence of endometrial cancer is increasing worldwide. While delays in diagnosis reduce survival, case molecular misclassification might be associated with under- and over-treatment. The objective of this study was to evaluate genetic alterations to detect and molecularly classify cases of endometrial cancer using non-invasive samples. METHODS: Consecutive patients with incident endometrial...
Topics
- Female
- Humans
- Case-Control Studies
- Endometrial Neoplasms
- Mutation
- Prognosis
- Europe