Mini tryptophanyl-tRNA synthetase is required for a synthetic phenotype in vascular smooth muscle cells induced by IFN-γ-mediated β2-adrenoceptor signaling.

doi:10.1016/j.cyto.2019.154940

Article

Mini tryptophanyl-tRNA synthetase is required for a synthetic phenotype in vascular smooth muscle cells induced by IFN-γ-mediated β2-adrenoceptor signaling.

Cytokine - 1 Mar 2020

Biros Erik, Moran Corey S

Abstract excerpt

Phenotypic modulation of vascular smooth muscle cells (AoSMCs) between quiescent 'contractile' and active 'synthetic' states is crucial in response to normal stimuli and pathological stressors. Previous studies have revealed the ability of interferon gamma (IFN-γ) to activate and promote a synthetic phenotype in AoSMCs that parallels marked up-regulation of truncated tryptophanyl-tRNA synthetase (mini-TrpRS)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Mini tryptophanyl-tRNA synthetase is required for a synthetic phenotype in vascular smooth muscle cells induced by IFN-γ-mediated β2-adrenoceptor signaling.

Abstract excerpt

Topics

Related research