Article
Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms.
Blood - 23 Feb 2023
Pecquet Christian, Papadopoulos Nicolas, Balligand Thomas, Chachoua Ilyas, Tisserand Amandine, Vertenoeil Gaëlle, Nédélec Audrey, Vertommen Didier, Roy Anita, Marty Caroline, Nivarthi Harini, Defour Jean-Philippe, El-Khoury Mira, Hug Eva, Majoros Andrea, Xu Erica, Zagrijtschuk Oleh, Fertig Tudor E, Marta Daciana S, Gisslinger Heinz, Gisslinger Bettina, Schalling Martin, Casetti Ilaria, Rumi Elisa, Pietra Daniela, Cavalloni Chiara, Arcaini Luca, Cazzola Mario, Komatsu Norio, Kihara Yoshihiko, Sunami Yoshitaka, Edahiro Yoko, Araki Marito, Lesyk Roman, Buxhofer-Ausch Veronika, Heibl Sonja, Pasquier Florence, Havelange Violaine, Plo Isabelle, Vainchenker William, Kralovics Robert, Constantinescu Stefan N
Abstract excerpt
Mutant calreticulin (CALR) proteins resulting from a -1/+2 frameshifting mutation of the CALR exon 9 carry a novel C-terminal amino acid sequence and drive the development of myeloproliferative neoplasms (MPNs). Mutant CALRs were shown to interact with and activate the thrombopoietin receptor (TpoR/MPL) in the same cell. We report that mutant CALR proteins are secreted and can be found in patient plasma at levels...
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