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Article

Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats.

Scientific reports - 28 Nov 2019

Napso Tina, Hung Yin-Po, Davidge Sandra T, Care Alison S, Sferruzzi-Perri Amanda N

Abstract excerpt

Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This study in the rat assessed the impact of advanced maternal age on placental phenotype in relation to the growth of female and male fetuses. We show that relative to young (3-4 months) dams,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31780670
DOI: 10.1038/s41598-019-53199-x
PMCID: PMC6882885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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