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Article

Aging Endocrine and Metabolic Phenotypes Are Programmed by Mother's Age at Conception in a Sex-Dependent Fashion in the Rat.

The journals of gerontology. Series A, Biological sciences and medical sciences - 13 Nov 2020

Zambrano Elena, Reyes-Castro Luis A, Rodríguez-González Guadalupe L, Chavira Roberto, Nathanielsz Peter W

Abstract excerpt

Programming of offspring life-course health by maternal nutrition and stress are well studied. At postnatal day 850, we evaluated male and female steroid levels and metabolism in aged offspring of primigravid sister rats bred at 70, 90, 150, or 300 days' life. At 850 days life, male offspring corticosterone was similar regardless of maternal age. Female corticosterone was highest in offspring of 70- and 300-day...

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PMID: 32154556
DOI: 10.1093/gerona/glaa067

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