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Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson's disease patient with mutant PINK1 (p. I368N).

Stem cell research - 1 Dec 2019

Abdul Mazid Md, Ibañez David P, Zhao Ping, Liu Hao, Zhong Xiaofen, Li Yingying, Zhang Meng, Li Wenjuan, Li Yunpan, Ward Carl, Chen Shuhan, Wang Dongye, Qin Baoming, Esteban Miguel A, Wang Xiwei, Fan Wenxia, Luo Zhiwei

Abstract excerpt

Familial Parkinson's disease (PD) can be caused by deleterious mutations in PINK1 (encoding PINK1) in an autosomal recessive manner. Functional studies suggest that PINK1 works as a regulator of mitochondrial homeostasis. However, how loss of PINK1 induces dopaminergic neuron degeneration is still unclear. Here, we have generated a patient-derived induced pluripotent stem cell (iPSC) line with mutant PINK1 (p....

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Identifiers

PMID: 31778937
DOI: 10.1016/j.scr.2019.101607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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