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Article

Inhibition of DKC1 induces telomere-related senescence and apoptosis in lung adenocarcinoma

20 Apr 2021

Abstract excerpt

BACKGROUND: Lung cancer is one of the most widely spread cancers in the world and half of the non-small cell lung cancers are lung adenocarcinoma (LUAD). Although there were several drugs been approved for LUAD therapy, a large portion of LUAD still cannot be effectively treated due to lack of available therapeutic targets. Here, we investigated the oncogenic roles of DKC1 in LUAD and its potential mechanism and...

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PMID: 33879171
DOI: 10.1186/s12967-021-02827-0

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