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FGF Signalling in the Self-Renewal of Colon Cancer Organoids

22 Nov 2019

Abstract excerpt

The progression of colorectal cancer (CRC) is supposedly driven by cancer stem cells (CSC) which are able to self-renew and simultaneously fuel bulk tumour mass with highly proliferative and differentiated tumour cells. However, the CSC-phenotype in CRC is unstable and dependent on environmental cues. Fibroblast growth factor 2 (FGF2) is essential and necessary for the maintenance of self-renewal in adult and...

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PMID: 31758153
DOI: 10.1038/s41598-019-53907-7

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