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Article

An Escherichia coli ST131 pangenome atlas reveals population structure and evolution across 4,071 isolates.

Scientific reports - 22 Nov 2019

Decano Arun Gonzales, Downing Tim

Abstract excerpt

Escherichia coli ST131 is a major cause of infection with extensive antimicrobial resistance (AMR) facilitated by widespread beta-lactam antibiotic use. This drug pressure has driven extended-spectrum beta-lactamase (ESBL) gene acquisition and evolution in pathogens, so a clearer resolution of ST131's origin, adaptation and spread is essential. E. coli ST131's ESBL genes are typically embedded in mobile genetic...

Topics

Drug Resistance, Multiple, Bacterial
Epidemics
Escherichia coli
Escherichia coli Infections
Escherichia coli Proteins
Evolution, Molecular
Genome, Bacterial
Genomics
Genotype
Geography
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Epidemiology

Phylogeny

Plasmids

Sequence Analysis, DNA

beta-Lactamases

Source

Open in PubMed Open full text

Identifiers

PMID: 31758048
DOI: 10.1038/s41598-019-54004-5
PMCID: PMC6874702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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