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Article

DNA methylation profile is a quantitative measure of biological aging in children

22 Nov 2019

Abstract excerpt

DNA methylation changes within the genome can be used to predict human age. However, the existing biological age prediction models based on DNA methylation are predominantly adult-oriented. We established a methylation-based age prediction model for children (9-212 months old) using data from 716 blood samples in 11 DNA methylation datasets. Our elastic net model includes 111 CpG sites, mostly in genes associated...

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PMID: 31756171
DOI: 10.18632/aging.102399

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