USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer

Abstract excerpt

Dear Editor, The Hippo tumor suppressor pathway plays an important role in development and tumorigenesis. Yes-associated protein (YAP) is a major effector of the Hippo pathway regulating the expression of genes involved in cell proliferation, cell death, and cell differentiation (Pan, 2010; Johnson and Halder, 2014; Piccolo et al., 2014; Yu et al., 2015). In intestine, YAP is mainly expressed in leucine rich...

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