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Article

Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability

17 Apr 2017

Abstract excerpt

Hippo signaling controls the expression of genes regulating cell proliferation and survival and organ size. The regulation of core components in the Hippo pathway by phosphorylation has been extensively investigated, but the roles of ubiquitination-deubiquitination processes are largely unknown. To identify deubiquitinase(s) that regulates Hippo signaling, we performed unbiased siRNA screening and found that YOD1...

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PMID: 28416659
DOI: 10.1073/pnas.1620306114

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