Associations of Genetic Variants in Uric Acid Transporter Genes With Salt Sensitivity, Longitudinal Blood Pressure Changes, and Incident Hypertension in Chinese Adults.

doi:10.1111/jch.70361

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Article

Associations of Genetic Variants in Uric Acid Transporter Genes With Salt Sensitivity, Longitudinal Blood Pressure Changes, and Incident Hypertension in Chinese Adults.

Journal of clinical hypertension (Greenwich, Conn.) - 1 Sept 2026

Chang Ming-Ke, Kong Ling-Yun, Zhang Zhuo-Ran, Yao Shi, Wang Xin, Li Hao, Wang Yang, Gao Wei-Hua

Abstract excerpt

Uric acid transporters mediate renal and extrarenal urate handling and may contribute to blood pressure (BP) regulation. This study examined the associations of common single-nucleotide polymorphisms (SNPs) in key urate transporter genes (SLC2A9, ABCG2, SLC17A3, SLC22A7, SLC22A6, SLC22A11, SLC22A12, and ABCC4) with salt sensitivity, longitudinal BP changes, and incident hypertension. Data were derived from the...

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Topics

Adult
Female
Humans
Male
Middle Aged
ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

ATP-Binding Cassette, Sub-Family C Proteins

Blood Pressure

China

Glucose Transport Proteins, Facilitative

Hypertension

Incidence

Longitudinal Studies

Neoplasm Proteins

Organic Anion Transporters

Organic Cation Transport Proteins

Polymorphism, Single Nucleotide

Prospective Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 42745169
DOI: 10.1111/jch.70361
PMCID: PMC13578107

Genes

DBP
ABCC4
ABCG2
SLC22A12
SLC22A6
SLC2A9
SLC17A3
SLC22A11
SLC22A7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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