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Article

MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial therapy.

Pharmacogenomics - 1 Jul 2017

Vos Karin, Sciuto Carlotta Lo, Piedade Rita, Ashton Michael, Björkman Anders, Ngasala Billy, Mårtensson Andreas, Gil José Pedro

Abstract excerpt

AIM: To investigate the potential involvement of the hepatic ATP-binding cassette transporters MRP2 and MDR1 in the disposition of lumefantrine (LUM) among patients with uncomplicated Plasmodium falciparum malaria. MATERIALS & METHODS: The tag SNPs MDR1/ABCB1 C3435T and MRP2/ABCC2 C1515Y were determined in two artemether-LUM clinical trials, including a pharmacokinetic/pharmacodynamic study focused on the...

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Identifiers

PMID: 28639487
DOI: 10.2217/pgs-2017-0032

Genes

LUM
ABCC2
ABCB1

Variants

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