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Article

The co-influence of VWD type 2B/2M mutations in the A1 domain and platelet GPIbα on the rate of cleavage to VWF by ADAMTS13.

Thrombosis research - 1 Nov 2015

Ma Zhenni, Su Jian, Zhang Jingyu, Ling Jing, Yin Jie, Bai Xia, Ruan Changgeng

Abstract excerpt

INTRODUCTION: In plasma, the size of the von Willebrand factor (VWF) multimer is down-regulated by ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13). The binding of platelets or glycoprotein (GP) Ibα recombinant fragment to VWF domain A1 may increase the cleavage by ADAMTS13 to VWF. Both type 2B and type 2M von Willebrand disease (VWD) result in bleeding disorders with the...

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Source

Identifiers

PMID: 26345337
DOI: 10.1016/j.thromres.2015.08.008

Genes

ADAMTS13
VWF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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