Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction.

eLife - 20 Nov 2019

Toubiana Shir, Gagliardi Miriam, Papa Mariarosaria, Manco Roberta, Tzukerman Maty, Matarazzo Maria R, Selig Sara

Abstract excerpt

DNA methyltransferase 3B (DNMT3B) is the major DNMT that methylates mammalian genomes during early development. Mutations in human DNMT3B disrupt genome-wide DNA methylation patterns and result in ICF syndrome type 1 (ICF1). To study whether normal DNA methylation patterns may be restored in ICF1 cells, we corrected DNMT3B mutations in induced pluripotent stem cells from ICF1 patients. Focusing on repetitive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methyltransferase 3B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Histones

Share to Induced Pluripotent Stem Cells

Share to Primary Immunodeficiency Diseases

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 31738163
DOI: 10.7554/eLife.47859
PMCID: PMC6897513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction.PMID 31738163Read ↗

Induced pluripotent stem cells as a model for telomeric abnormalities in ICF type I syndromeSemantic proximity Read ↗

The rescue of epigenomic abnormalities in ICF1 patient iPSCs following <i>DNMT3B</i> correction is incomplete at a residual fraction of H3K4me3-enriched regionsSemantic proximity Read ↗

Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cellsSemantic proximity Read ↗

Characterization and rescue of telomeric abnormalities in ICF syndrome type I fibroblastsSemantic proximity Read ↗

ICF1-Syndrome-Associated DNMT3B Mutations Prevent De Novo Methylation at a Subset of Imprinted Loci during iPSC Reprogramming.Semantic proximity Read ↗

Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regionsSemantic proximity Read ↗

Subtelomeric methylation distinguishes between subtypes of Immunodeficiency, Centromeric instability and Facial anomalies syndrome.Semantic proximity Read ↗

Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state.Semantic proximity Read ↗

Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for DiseasesSemantic proximity Read ↗

TERRA, CpG methylation, and telomere heterochromatin: Lessons from ICF syndrome cellsSemantic proximity Read ↗

Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations.Semantic proximity Read ↗

DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.