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Article

TERRA, CpG methylation, and telomere heterochromatin: Lessons from ICF syndrome cells

1 Jan 2010

Abstract excerpt

Self-reinforcing negative feedback loops are commonly observed in biological systems. RNA-mediated negative feedback loops have been described in the formation of heterochromatin at centromeres in fission yeast and the inactive X chromosome in mammalian cells. The telomere repeat-containing RNA (TERRA) has also been implicated in the formation of telomeric heterochromatin through a self-reinforcing negative...

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Share to Advanced biosensing and bioanalysis techniques
Share to RNA regulation and disease
Share to Telomeres, Telomerase, and Senescence

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PMID: 20016274
DOI: 10.4161/cc.9.1.10358

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