Article
Molecular Dynamics Simulation Reveals Exposed Residues in the Ligand-Binding Domain of the Low-Density Lipoprotein Receptor that Interacts with Vesicular Stomatitis Virus-G Envelope.
Viruses - 15 Nov 2019
Al-Allaf Faisal A, Abduljaleel Zainularifeen, Taher Mohiuddin M, Abdellatif Ahmed A H, Athar Mohammad, Bogari Neda M, Al-Ahdal Mohammed N, Al-Mohanna Futwan, Al-Hassnan Zuhair N, Alzabeedi Kamal H Y, Banssir Talib M, Bouazzaoui Abdellatif
Abstract excerpt
Familial hypercholesterolemia (FH) is an autosomal dominant disease most often caused by mutations in the low-density lipoprotein receptor (LDLR) gene, which consists of 18 exons spanning 45 kb and codes for a precursor protein of 860 amino acids. Mutations in the LDLR gene lead to a reduced hepatic clearance of LDL as well as a high risk of coronary artery disease (CAD) and sudden cardiac death (SCD). Recently,...
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