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Abolishing Retro-Transduction of Producer Cells in Lentiviral Vector Manufacturing

29 Jul 2024

Abstract excerpt

Transduction of producer cells during lentiviral vector (LVV) production causes the loss of 70-90% of viable particles. This process is called retro-transduction and it is a consequence of the interaction between the LVV envelope protein, VSV-G, and the LDL receptor located on the producer cell membrane, allowing lentiviral vector transduction. Avoiding retro-transduction in LVV manufacturing is crucial to...

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PMID: 39205190
DOI: 10.3390/v16081216

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