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Article

Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein

6 Mar 2018

Abstract excerpt

Vesicular stomatitis virus (VSV) is an oncolytic rhabdovirus and its glycoprotein G is widely used to pseudotype other viruses for gene therapy. Low-density lipoprotein receptor (LDL-R) serves as a major entry receptor for VSV. Here we report two crystal structures of VSV G in complex with two distinct cysteine-rich domains (CR2 and CR3) of LDL-R, showing that their binding sites on G are identical. We identify...

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PMID: 29531262
DOI: 10.1038/s41467-018-03432-4

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