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Article

Celiac disease associated SNP rs17810546 is located in a gene silencing region.

Gene - 5 Feb 2020

Zwiers Antonie, van Wanrooij Roy L J, Dieckman Tessa, Nijeboer Petula, Kraal Georg, Bouma Gerd

Abstract excerpt

GWAS studies have identified variant rs 17810546 in a non-coding region on chromosome 3 as a risk factor for several auto-immune diseases, including Celiac Disease. In silico analysis reveals that this variant is located in a transcription regulatory site. By means of reporter constructs we show that this region can override the expression rate of a gene as determined by its native promoter and that this...

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PMID: 31726085
DOI: 10.1016/j.gene.2019.144165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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