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Cefiderocol: A Novel Siderophore Cephalosporin Defeating Carbapenem-resistant Pathogens

16 Oct 2019

Abstract excerpt

Cefiderocol, a novel siderophore cephalosporin in late-stage clinical development, utilizes a "Trojan horse" active transport mechanism to enter bacteria and has proven in vitro activity against carbapenem-resistant gram-negative pathogens, including those with major carbapenem-resistance mechanisms, and stability against all carbapenemases.

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PMID: 31724046
DOI: 10.1093/cid/ciz823

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