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Article

Allosteric modulators restore orthosteric agonist binding to mutated CB1 receptors.

The Journal of pharmacy and pharmacology - 1 Jan 2020

Dopart Rachel, Kendall Debra A

Abstract excerpt

OBJECTIVES: To determine if diminished orthosteric agonist binding due to mutations in extracellular loops 1 or 2 of the cannabinoid receptor 1 (CB1 ) can be overcome by an allosteric modulator and restore agonist binding. METHODS: Binding assays were performed using a range of concentrations of orthosteric compound, in the presence or absence of a set concentration of the allosteric modulator PSNCBAM-1 to...

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Identifiers

PMID: 31722122
DOI: 10.1111/jphp.13193
PMCID: PMC6906232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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