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Article

Monod-Wyman-Changeux allosteric mechanisms of action and the pharmacology of etomidate.

Current opinion in anaesthesiology - 1 Aug 2012

Forman Stuart A

Abstract excerpt

PURPOSE OF REVIEW: Formal Monod-Wyman-Changeux allosteric mechanisms have proven valuable in framing research on the mechanism of etomidate action on its major molecular targets, γ-aminobutyric acid type A (GABAA) receptors. However, the mathematical formalism of these mechanisms makes them difficult to comprehend. RECENT FINDINGS: We illustrate how allosteric models represent shifting equilibria between various...

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Identifiers

PMID: 22614249
DOI: 10.1097/ACO.0b013e328354feea
PMCID: PMC3673006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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