Psychosocial effects of whole-body MRI screening in adult high-risk pathogenic TP53 mutation carriers: a case-controlled study (SIGNIFY).

doi:10.1136/jmedgenet-2019-106407

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Article

Psychosocial effects of whole-body MRI screening in adult high-risk pathogenic TP53 mutation carriers: a case-controlled study (SIGNIFY).

Journal of medical genetics - 1 Apr 2020

Bancroft Elizabeth K, Saya Sibel, Brown Emma, Thomas Sarah, Taylor Natalie, Rothwell Jeanette, Pope Jennifer, Chamberlain Anthony, Page Elizabeth, Benafif Sarah, Hanson Helen, Dias Alexander, Mikropoulos Christos, Izatt Louise, Side Lucy, Walker Lisa, Donaldson Alan, Cook Jackie A, Barwell Julian, Wiles Vicki, Limb Lauren, Eccles Diana M, Leach Martin O, Shanley Susan, Gilbert Fiona J, Gallagher David, Rajashanker Balashanmugam, Whitehouse Richard W, Koh Dow-Mu, Sohaib S Aslam, Evans D Gareth, Eeles Rosalind A, Walker Leslie G

Abstract excerpt

BACKGROUND: Germline TP53 gene pathogenic variants (pv) cause a very high lifetime risk of developing cancer, almost 100% for women and 75% for men. In the UK, annual MRI breast screening is recommended for female TP53 pv carriers. The SIGNIFY study (Magnetic Resonance Imaging screening in Li Fraumeni syndrome: An exploratory whole body MRI) study reported outcomes of whole-body MRI (WB-MRI) in a cohort of 44...

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Identifiers

PMID: 31719169
DOI: 10.1136/jmedgenet-2019-106407
PMCID: PMC7146942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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