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Rates of Intervention and Cancer Detection on Initial versus Subsequent Whole-body MRI Screening in Li-Fraumeni Syndrome.

Cancer prevention research (Philadelphia, Pa.) - 1 Sept 2023

Kagami Laura A T, Du Yun K, Fernandes Conrad J, Le Anh N, Good Madeline, Duvall Melani M, Baldino Sarah E, Powers Jacquelyn, Zelley Kristin, States Lisa J, Mathew Manoj C, Katona Bryson W, MacFarland Suzanne P, Maxwell Kara N

Abstract excerpt

Li-Fraumeni Syndrome (LFS) is a hereditary cancer predisposition syndrome with up to 90% lifetime cancer risk. Cancer screening, including annual whole-body MRI (WB-MRI), is recommended due to known survival advantage, with cancer detection rate of 7% on initial screening. Intervention and cancer detection rates on subsequent screenings are unknown. Clinical data for pediatric and adult patients with LFS (n =...

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PMID: 37428016
DOI: 10.1158/1940-6207.CAPR-23-0011

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