Article
Surveillance recommendations for patients with germline TP53 mutations.
Current opinion in oncology - 1 Jul 2015
Ballinger Mandy L, Mitchell Gillian, Thomas David M
Abstract excerpt
PURPOSE OF REVIEW: Li-Fraumeni syndrome is associated with germline TP53 mutations and carriers have a high lifetime risk of cancer, the most common being sarcoma, breast cancer, brain tumors, adrenocortical carcinoma and leukemia. Germline TP53 mutation carriers are increasingly being identified as more genomic sequencing is performed in both clinical and research settings. There is a pressing clinical need for...
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