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Article

Toll-like receptor 5 in obesity: the role of gut microbiota and adipose tissue inflammation.

Obesity (Silver Spring, Md.) - 1 Mar 2015

Pekkala Satu, Munukka Eveliina, Kong Lingjia, Pöllänen Eija, Autio Reija, Roos Christophe, Wiklund Petri, Fischer-Posovszky Pamela, Wabitsch Martin, Alen Markku, Huovinen Pentti, Cheng Sulin

Abstract excerpt

OBJECTIVE: This study aimed at establishing bacterial flagellin-recognizing toll-like receptor 5 (TLR5) as a novel link between gut microbiota composition, adipose tissue inflammation, and obesity. METHODS: An adipose tissue microarray database was used to compare women having the highest (n = 4, H-TLR) and lowest (n = 4, L-TLR) expression levels of TLR5-signaling pathway genes. Gut microbiota composition was...

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Source

Identifiers

PMID: 25611816
DOI: 10.1002/oby.20993

Genes

TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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