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Article

Clinical considerations in individuals with α1-antitrypsin PI*SZ genotype.

The European respiratory journal - 1 Jun 2020

McElvaney Gerard N, Sandhaus Robert A, Miravitlles Marc, Turino Gerard M, Seersholm Niels, Wencker Marion, Stockley Robert A

Abstract excerpt

α1-Antitrypsin deficiency (AATD), characterised by reduced levels or functionality of α1-antitrypsin (AAT), is a significantly underdiagnosed genetic condition that predisposes individuals to lung and liver disease. Most of the available data on AATD are based on the most common, severe deficiency genotype (PI*ZZ); therefore, treatment and monitoring requirements for individuals with the PI*SZ genotype, which is...

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Identifiers

PMID: 32165400
DOI: 10.1183/13993003.02410-2019
PMCID: PMC7301289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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