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Adenovirus vectors in hematopoietic stem cell genome editing

9 Nov 2019

Abstract excerpt

Genome editing of hematopoietic stem cells (HSCs) represents a therapeutic option for a number of hematological genetic diseases, as HSCs have the potential for self‐renewal and differentiation into all blood cell lineages. This review presents advances of genome editing in HSCs utilizing adenovirus vectors as delivery vehicles. We focus on capsid‐modified, helper‐dependent adenovirus vectors that are devoid of...

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PMID: 31705806
DOI: 10.1002/1873-3468.13668

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