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Article

Analysis of the meiotic recombination gene REC8 for sequence variations in a population with severe male factor infertility.

Systems biology in reproductive medicine - 1 Jan 2000

Griffin Jeanine, Emery Benjamin R, Christensen Greg L, Carrell Douglas T

Abstract excerpt

Proper regulation of meiosis is essential for normal spermatogenesis and abnormalities may be associated with infertility, as shown in both animal knockout studies and studies identifying anomalies in key proteins, such as SCP3 and MLH1. Disruptions of meiosis are associated with azoospermia or severe oligozoospermia, and may increase the incidence of sperm aneuploidy in some men. Based on its function and animal...

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Source

Identifiers

PMID: 18570052
DOI: 10.1080/19396360802061317

Genes

REC8
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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