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Article

Unbiased Estimation of Linkage Disequilibrium from Unphased Data.

Molecular biology and evolution - 1 Mar 2020

Ragsdale Aaron P, Gravel Simon

Abstract excerpt

Linkage disequilibrium (LD) is used to infer evolutionary history, to identify genomic regions under selection, and to dissect the relationship between genotype and phenotype. In each case, we require accurate estimates of LD statistics from sequencing data. Unphased data present a challenge because multilocus haplotypes cannot be inferred exactly. Widely used estimators for the common statistics r2 and D2...

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Identifiers

PMID: 31697386
DOI: 10.1093/molbev/msz265
PMCID: PMC7038669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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