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Article

Inferring the history of population size change from genome-wide SNP data.

Molecular biology and evolution - 1 Dec 2012

Theunert Christoph, Tang Kun, Lachmann Michael, Hu Sile, Stoneking Mark

Abstract excerpt

Dense, genome-wide single-nucleotide polymorphism (SNP) data can be used to reconstruct the demographic history of human populations. However, demographic inferences from such data are complicated by recombination and ascertainment bias. We introduce two new statistics, allele frequency-identity by descent (AF-IBD) and allele frequency-identity by state (AF-IBS), that make use of linkage disequilibrium...

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PMID: 22787284
DOI: 10.1093/molbev/mss175

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