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Article

Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's disease.

Scientific reports - 6 Nov 2019

Irvine Elaine E, Katsouri Loukia, Plattner Florian, Al-Qassab Hind, Al-Nackkash Rand, Bates Gillian P, Withers Dominic J

Abstract excerpt

Huntington's disease (HD) is a fatal inherited autosomal dominant neurodegenerative disorder caused by an expansion in the number of CAG trinucleotide repeats in the huntingtin gene. The disease is characterized by motor, behavioural and cognitive symptoms for which at present there are no disease altering treatments. It has been shown that manipulating the mTOR (mammalian target of rapamycin) pathway using...

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Identifiers

PMID: 31695068
DOI: 10.1038/s41598-019-52391-3
PMCID: PMC6834565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's disease.PMID 31695068Read ↗

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Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.Semantic proximity Read ↗

S6k1 is not required for Pten-deficient neuronal hypertrophy.Semantic proximity Read ↗

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Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.Semantic proximity Read ↗

Rhes Deletion Prevents Age-Dependent Selective Motor Deficits and Reduces Phosphorylation of S6K in Huntington Disease Hdh150Q(CAG) Knock-In MiceSemantic proximity Read ↗

Overexpression of heat shock protein 70 in R6/2 Huntington’s disease mice has only modest effects on disease progressionSemantic proximity Read ↗

Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.Semantic proximity Read ↗

Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease.Semantic proximity Read ↗

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