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Article

Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease.

PloS one - 1 Jun 2009

Benn Caroline L, Butler Rachel, Mariner Lydia, Nixon Jude, Moffitt Hilary, Mielcarek Michal, Woodman Ben, Bates Gillian P

Abstract excerpt

Huntington's disease (HD) is an inherited, progressive neurological disorder caused by a CAG/polyglutamine repeat expansion, for which there is no effective disease modifying therapy. In recent years, transcriptional dysregulation has emerged as a pathogenic process that appears early in disease progression. Administration of histone deacetylase (HDAC) inhibitors such as suberoylanilide hydroxamic acid (SAHA)...

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Identifiers

PMID: 19484127
DOI: 10.1371/journal.pone.0005747
PMCID: PMC2684627

Genes

HDAC7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease.PMID 19484127Read ↗

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