Article
GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency.
The Journal of clinical investigation - 1 May 2013
Ye Ping, Chen Wenhao, Wu Jie, Huang Xiaofan, Li Jun, Wang Sihua, Liu Zheng, Wang Guohua, Yang Xiao, Zhang Peng, Lv Qiulun, Xia Jiahong
Abstract excerpt
Heterozygous loss-of-function SMAD3 (Mothers against decapentaplegic homolog 3) mutations lead to aneurysm-osteoarthritis syndrome (AOS). In the present study, we found that mice lacking Smad3 had a vascular phenotype similar to AOS, marked by the progressive development of aneurysms. These aneurysms were associated with various pathological changes in transmural inflammatory cell infiltration. Bone marrow...
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