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Article

CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation.

The Journal of biological chemistry - 17 Oct 2003

Ubeda Mariano, Habener Joel F

Abstract excerpt

The CAAT/enhancer binding protein homologous transcription factor CHOP, also known as GADD153, is involved in DNA damage, growth arrest, and the induction of apoptosis after endoplasmic reticulum stress and nutrient deprivation. CHOP dimerizes with and inhibits the binding of C/EBP-related transc...

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Source

Identifiers

PMID: 12876286
DOI: 10.1074/jbc.M306404200

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12876286-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation.PMID 12876286Read ↗

Transcription Factor C/EBP Homologous Protein in Health and DiseasesSemantic proximity Read ↗

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Molecular Symbiosis of CHOP and C/EBPβ Isoform LIP Contributes to Endoplasmic Reticulum Stress-Induced ApoptosisSemantic proximity Read ↗

The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and OncogenesisSemantic proximity Read ↗

CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation.Semantic proximity Read ↗

Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response.Semantic proximity Read ↗

PERK-mediated induction of miR-5p and miR-3p arms of miR-616 regulates cell growth by targeting c-MYCSemantic proximity Read ↗

Regulated translation initiation controls stress-induced gene expression in mammalian cells.Semantic proximity Read ↗

HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia.Semantic proximity Read ↗

Stress-Inducible Transcription Factor CHOP/gadd153 Induces Apoptosis in Mammalian Cells via p38 Kinase-Dependent and -Independent MechanismsSemantic proximity Read ↗

Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR.Semantic proximity Read ↗

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