Article
Atm reactivation reverses ataxia telangiectasia phenotypes in vivo.
Cell death & disease - 22 Feb 2018
Di Siena Sara, Campolo Federica, Gimmelli Roberto, Di Pietro Chiara, Marazziti Daniela, Dolci Susanna, Lenzi Andrea, Nussenzweig Andre, Pellegrini Manuela
Abstract excerpt
Hereditary deficiencies in DNA damage signaling are invariably associated with cancer predisposition, immunodeficiency, radiation sensitivity, gonadal abnormalities, premature aging, and tissue degeneration. ATM kinase has been established as a central player in DNA double-strand break repair and its deficiency causes ataxia telangiectasia, a rare, multi-system disease with no cure. So ATM represents a highly...
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