Article
Bone marrow transplantation improves the outcome of Atm-deficient mice through the migration of ATM-competent cells.
Human molecular genetics - 1 Feb 2013
Pietzner J, Baer P C, Duecker R P, Merscher M B, Satzger-Prodinger C, Bechmann I, Wietelmann A, Del Turco D, Doering C, Kuci S, Bader P, Schirmer S, Zielen S, Schubert R
Abstract excerpt
Ataxia telangiectasia (A-T) is a highly pleiotropic disorder. Patients suffer from progressive neurodegeneration, severe bronchial complications, immunodeficiency, hypersensitivity to radiotherapy and elevated risk of malignancies. Leukemia and lymphoma, along with lung failure, are the main causes of morbidity and mortality in A-T patients. At present, no effective therapy for A-T exists. One promising...
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