Article
Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours.
British journal of cancer - 9 Aug 2011
Reiman A, Srinivasan V, Barone G, Last J I, Wootton L L, Davies E G, Verhagen M M, Willemsen M A, Weemaes C M, Byrd P J, Izatt L, Easton D F, Thompson D J, Taylor A M
Abstract excerpt
BACKGROUND: Immunodeficiency in ataxia telangiectasia (A-T) is less severe in patients expressing some mutant or normal ATM kinase activity. We, therefore, determined whether expression of residual ATM kinase activity also protected against tumour development in A-T. METHODS: From a total of 296 consecutive genetically confirmed A-T patients from the British Isles and the Netherlands, we identified 66 patients...
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