Article
Expression, purification, and structural analysis of the full-length human integral membrane protein γ-sarcoglycan.
Protein expression and purification - 1 Mar 2020
Jamaleddine Michael, Harris Michael S, Liyanage Leshani, Cook Gabriel A
Abstract excerpt
Mutation of the gene encoding γ-sarcoglycan (SGCG), an integral membrane protein responsible for maintaining the integrity of the muscle cell sarcolemma, results in Limb-Girdle Muscular Dystrophy (LGMD), a congenital disease with no current treatment options. This member of the sarcoglycan glycoprotein family is a vital component of the Dystrophin Complex, which together facilitate normal muscle function....
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